Panagiotis Moulos holds a diploma in Applied Mathematics and Physics from the National Technical University of Athens (NTUA) and an MSc in Bioinformatics from the Free University of Brussels (ULB). He is currently a post-doctoral researcher in the Renal Fibrosis Lab, I2MC, Toulouse, France under the supervision of Dr. Joost Schanstra. Among others, his research interests include algorithms for the computational analysis and meta-analysis of high-throughput genomic data (DNA microarrays), relative software development and focus on statistical properties, statistical modeling and normalization of Next Generation Sequencing (NGS) data (ChIP-Seq, RNA-Seq). He is also interested in the application of Machine Learning techniques regarding the computational analysis of high-throughput genomic data with focus on dimensionality reduction and feature selection stability issues and recently developed interest on the analysis and meta-analysis of metabolomics MS data. Particular interest is given to the integration of lower level data representations (fundamental analysis of high-throughput genomic data) to higher level representations (over represented GO categories, mapping to metabolic pathways, building of transcriptional networks). Future goals include integration of NGS analytical methodologies to a common analysis workflow including data from other high-throughput genomic techniques (e.g. expression microarrays) and the setup of large scale mathematical models of specific metabolic pathways in order to approach functionalities in a systemic way. His practical skills include excellent operation and software development using statistical and engineering packages such as MatLab and R, programming skills in Perl, Java, PHP and MySQL and excellent familiarity with several bioinformatics data analysis tools encompassing a variety of data types (sequence, microarray and next generation sequencing data analysis) and usage and handling of biological databases.
Panagiotis Moulos has collaborated as a bioinformatics expert with the group of Prof. H.G. Stunnenberg (NCMLS, Radboud University) in two projects: i) the study of genome-wide binding profile of the transcription factor complex PPARγ:RXR coupled with the study of RNA polymerase II occupancy to study gene expression in 3T3-L1 murine cells during adipogenesis and ii) the study of the genome-wide binding profile of the transcription factors GR and NF-κB and the regulation of target genes through RNA polymerase II binding in HeLa cells, with both projects resulting in significant biological findings and relative publications. Other achievements include participation in the development of published microarray data analysis and meta-analysis software (Gene ARMADA, StRAnGER, GRISSOM portal) as well as establishment of analysis workflows for NGS data analysis with relative publications. Finally, Panagiotis Moulos has participated in the computational analysis and exploitation of several high-throughput genomic datasets, including the study of mastic-oil treatment effects in lung cancer mouse cells and the administration effects of several Polycyclic Aromatic Hydrocarbons in different dosage schemes in mouse liver and lung tissues, using microarray data. |